Recurrent Pregnancy Loss: What is recurrent pregnancy loss or RPL? Pregnancy loss or miscarriage happens to 15-20% of couples and most happen before 12 weeks of pregnancy. Recurrent pregnancy loss is defined by Indian Society of Reproductive Medicine (ISRM) as a condition defined by two or more failed pregnancies. Sadly, about 5% of couples will experience two consecutive miscarriages and less than 1% of couples will have three or more miscarriages. There are various known causes of recurrent pregnancy loss such as problems with the structure of the uterus, hormonal issues such as thyroid disorders, clotting issues such as antiphospholipid syndrome, genetic problems. However, with your second pregnancy loss, you can request your obgyn to send your miscarriage to have chromosome analysis as this is the most common cause for a miscarriage. If the chromosomes of your baby are abnormal, this will give you the most likely answer of why this happened. If the chromosomes are normal, other testing can be performed to understand the other reasons for pregnancy loss. Best Fertility Care Centre, Advanced Fertility Centre , Maternal & Child Health Care Centre , Ashwini Hospital & Fertility Centre Moondrumavadi K.Pudur Madurai -07.